Heme-Artemisinin Adducts Are Crucial Mediators of the Ability of Artemisinin to Inhibit Heme Polymerization
نویسندگان
چکیده
منابع مشابه
Artemisinin and heme.
A recent Letter to the Editor (R. K. Haynes, D. Monti, D. Taramelli, N. Basilico, S. Parapini, and P. Olliaro, Letter, Antimicrob. Agents Chemother. 47:1175, 2003) presented cogent evidence that artemisinin and its derivatives do not inhibit hemozoin formation in vitro. However, the authors misinterpret these data to conclude that “binding of artemisinins with Fe(III)PPIX is not necessary for a...
متن کاملTrioxaquines and heme-artemisinin adducts inhibit the in vitro formation of hemozoin better than chloroquine.
Trioxaquines, potential antimalarial agents, and heme-artemisinin adducts, resulting from the alkylation of heme by artemisinin, were evaluated as inhibitors of beta-hematin formation in 10 M acetate medium at pH 5.
متن کاملHeme - Artemisinin Adducts Inhibit the in vitro Formation of Hemozoin Better than Chloroquine
Christophe Loup Françoise Benoit-Vical Laboratoire de Chimie de Coordination CHU Rangueil CNRS Service de Parasitologie et Mycologie 205 Route de Narbonne 1 Av. Jean Poulhès 31000 Toulouse TSA 50032 phone: 00 33 5 61 33 31 48 31059 Toulouse cedex 9 fax.: 00 33 5 61 32 20 96 phone: 00 33 5 61 32 34 46 [email protected] fax.: 00 33 5 61 32 20 96 [email protected] AC...
متن کاملExtracellular heme enhances the antimalarial activity of artemisinin.
Artemisinin exerts the antimalarial activity through activation by heme. The hemolysis in malaria results in the elevated levels of plasma heme which may affect the activity of artemisinin. We hypothesized that the extracellular heme would potentiate the antimalarial activity of artemisinin. Hemin (ferric heme) at the pathologic concentrations enhanced the activity of artemisinin against Plasmo...
متن کاملThe antimalarial drug artemisinin alkylates heme in infected mice.
Heme alkylation by the antimalarial drug artemisinin is reported in vivo, within infected mice that have been treated at pharmacologically relevant doses. Adducts resulting from the alkylation of heme by the drug were characterized in the spleen of treated mice, and their glucuroconjugated derivatives were present in the urine. Because these heme-artemisinin adducts were not observed in noninfe...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2002
ISSN: 1074-5521
DOI: 10.1016/s1074-5521(02)00117-5